Developmental Changes in Action Potential Prolongation by K+-Channel Blockers in Chick Myocardium

Journal of Pharmacological Sciences

Hikaru Tanaka¹  Iyuki Namekata¹  Naoaki Kiryu¹  Shogo Hamaguchi¹  Mikio Kimata¹  Hideaki Nouchi¹  Akira Takahara¹  Koki Shigenobu¹  Yayoi Tsuneoka¹ 

[1] Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan

关键词: chick;    K+-channel blocker;    action potential duration;   

DOI  :  10.1254/jphs.10205SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(17)The effects of K+-channel blockers on the action potential duration of the myocardium were examined in isolated right ventricles from the 7 – 10-day-old, 11 – 13-day-old, and 14 – 20-day-old embryo and 1 – 7-day-old hatched chicks. E-4031 significantly prolonged action potential duration at all developmental stages examined; the prolongation was largest in the 11 – 13-day-old embryo and was accompanied by early after-depolarizations. Chromanol 293B showed smaller prolongation at all stages examined. Terfenadine prolonged action potential duration in the 11 – 13-day-old embryo, but not in other stages. Thus, the chick ventricular myocardium changes its repolarization properties during development.

【 授权许可】

Unknown