The Effects of Antipyretics on Influenza Virus Encephalitis in Mice and Chicks

Journal of Veterinary Medical Science

Akiko ANAGAWA²  Kazuya MATSUDA²  Takashi KIMURA²  Hiroshi KIDA¹  Kenji OCHIAI²  Yuji SUNDEN²  Takashi UMEMURA²  C.H. PARK² 

[1] Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University;Laboratory of Comparative Pathology, School of Veterinary Medicine, Hokkaido University

关键词: antipyretic;    chick;    encephalitis;    influenza;    mouse;   

DOI  :  10.1292/jvms.65.1185

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(20)Cited-By(3)To investigate the effect of antipyretics on the murine and poultry models of influenzal encephalitis, we injected large quantities of antipyretics, acetylsalicylic acid (aspirin) and dicrofenac sodium (voltaren). The effect of antipyretic treatment on the murine encephalitis model was unremarkable histologically and immunohistochemically. Whereas in chicks, CNS lesions consisting of perivascular cuffing and gliosis appeared only in those animals treated with the antipyretics and viral antigen was detected mainly in the nuclei of glial cells or vascular endothelia of voltaren-treated animals. We here demonstrate that antipyretic treatment aggravated the hematogenous spread of the influenza virus to the CNS in chicks, but did not affect the transneural infection in mice.

【 授权许可】

Unknown