Polymorphisms of the ApoE (Apolipoprotein E) Gene and Their Influence on Dyslipidemia in HIV-1-Infected Individuals

Japanese Journal of Infectious Diseases

Wasun Chantratita³  Apichaya Puangpetch¹  Tanida Suwalak¹  Pornpen Srisawasdi⁴  Angkana Charoenyingwattana²  Montri Chamnanphon¹  Napatrupron Koomdee¹  Chonlaphat Sukasem¹  Siwalee Santon¹ 

[1] Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University;Thailand Center of Excellence for Life Sciences, Ministry of Science and Technology;Division of Virology, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University;Division of Clinical Chemistry, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University

关键词: HIV-1;    dyslipidemias;    lipodystrophy;    Apolipoprotein E;    antiretroviral therapy;    pharmacogenetics;   

DOI  :  10.7883/yoken.JJID.2013.190

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

References(31)Cited-By(2)The purpose of this retrospective case-control study was to investigate the frequency of Apolipoprotein E (ApoE) polymorphisms and their influence on antiretroviral therapy (ART)-induced lipodystrophy or dyslipidemia in HIV-infected Thai patients. The clinical characteristics and frequencies of ApoE genotypes were compared between the case (moderate to severe lipodystrophy, n = 67) and control (absent to mild lipodystrophy, n = 18) groups. The ApoE genotype frequencies among the 85 participants were 2.35% (n = 2) for E2/E2, 20% (n = 17) for E2/E3, 9.41% (n = 8) for E2/E4, 36.47% (n = 31) for E3/E3, 30.59% (n = 26) for E3/E4, and 1.18% (n = 1) for E4/E4. None of the ApoE genotypes showed association with ART-induced lipodystrophy. However, the levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-cholesterol), and ApoB were lower in patients carrying the E2 allele but higher in E4 carriers. Interestingly, the ratios between TC and high-density lipoprotein (TC/HDL cholesterol ratio) and ApoB/ApoA-I ratio were significantly higher in the case group. Patients carrying the E2 allele displayed protective lipid profile, while those carrying E4 appeared to be at higher risk of dyslipidemia. In conclusion, ApoE polymorphisms were not associated with lipodystrophy in patients undergoing antiretroviral therapy but influenced lipid alteration.

【 授权许可】

Unknown