Adverse Drug Reactions in HIV/AIDS Patients at a Tertiary Care Hospital in Penang, Malaysia

Japanese Journal of Infectious Diseases

Syed Azhar Sulaiman²  Chow Ting Soo¹  Kashifullah Khan²  Ali Akhtar²  Amer Hayat Khan² 

[1] Infectious Disease Department, General Hospital Pulau Pinang;Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia

关键词: ADRs;    lipodystrophy;    HAART;    HIV/AIDS;   

DOI  :  10.7883/yoken.JJID.2014.246

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

References(30)In the current study we explored the occurrence of adverse drug reactions (ADRs) to antiretroviral therapy among human immune-deficiency virus (HIV)/AIDS patients. We concluded an observational retrospective study in all patients who were diagnosed with HIV infection and were receiving highly active antiviral therapy from Jan. 2007 to Dec. 2012 at Hospital Pulau Pinang, Malaysia. Patient socio-demographic details along with clinical features and susceptible ADRs were observed during the study period. Out of 743 patients, 571 (76.9%) were men, and 172 (23.1%) were women. Overall 314 (42.2%) patients experienced ADRs. A total of 425 ADRs were reported, with 311 (73.1%) occurring in men and 114 (26.8%) in women, with a significant statistical relationship (P value (P) = 0.02, OR = 1.21). Overall 239 (56.2%) ADRs were recorded among Chinese, 94 (22.1%) in Malay, and 71 (16.7%) in Indian patients, which had a statistically significant association with ADRs (P = 0.05, OR = 1.50). Out of a total 425 among ADRs, lipodystrophy was recorded in 151 (35.5%) followed by skin rashes in 80 (18.8%), anemia in 74 (17.4%), and peripheral neuropathy in 27 (6.3%) patients. These findings suggest a need of intensive monitoring of ADRs in HIV treatment centres across Malaysia.

【 授权许可】

Unknown