Clinical and epidemiological features of patients with chronic hepatitis C co-infected with HIV

Brazilian Journal of Infectious Diseases

Adriano, Silva¹  Rosicreuza, Marbak²  Fabrizio, Ney-Oliveira²  Lourianne, Nascimento²  Carlos, Brites¹  Eduardo Lorens, Braga²  Koonj Asvin, Shah³  Luiz Guilherme Costa, Lyra²  Manuel L., Ribeiro Neto⁴  André Castro, Lyra² 

[1] Federal University of Bahia, Salvador, Brazil;Federal University of Bahia;University of Texa, USA;University of Miami

关键词: Hepatitis C;    HIV;    co-infection;    clinical course;    HCV genotype;   

DOI  :  10.1590/S1413-86702006000100004

来源: Contexto

【 摘 要 】

Co-infection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is increasingly common and affects the clinical course of chronic hepatitis C. Highly active antiretroviral therapy has improved the life expectancy of HIV infected patients, but, by extending survival, it permits the development of HCV cirrhosis. This study tried to evaluate clinical and epidemiological features of patients with chronic hepatitis C co-infected with HIV. We evaluated 134 HCV-infected patients: i) group A – 65 co-infected HCV/HIV patients, ii) group B – 69 mono-infected HCV patients. The impact of HIV infection on HCV liver disease was analyzed using Child's score, ultrasound findings and liver histology. Patients were subjected to HCV genotyping and anti-HBs dosage. Patients mean age was 42.4 years (±9.1) and 97 (72.4%) were males. Injected drug use and homo/bisexual practice were more frequently encountered in the co-infected group: 68.3% and 78.0%, respectively. Antibodies against hepatitis B virus (anti-HBs) were found in only 38.1% of the patients (66.7% group A x 33.3% group B). Ten out of 14 individuals (71.4%) who had liver disease (Child B or C) and 25 out of 34 (73.5%) who showed ultrasound evidence of chronic liver disease were in the co-infection group. HCV genotype-2/3 was more frequently encountered in co-infected patients (36.9% group A vs. 21.8% group B). Conclusions: a) HIV infection seems to adversely affect the clinical course of chronic hepatitis C, b) injected drug use, bi/homosexual practice and genotype-2/3 were more frequently encountered in co-infected patients, c) immunization against HBV should be encouraged in these patients.

【 授权许可】

CC BY-NC-ND