Changes in Serum Sex Hormone Profiles after Short-term Low-dose Administration of Dehydroepiandrosterone (DHEA) to Young and Elderly Persons

Endocrine Journal

Atsushi NAKAJIMA³  Keigo YASUDA⁴  Hajime UESHIBA²  Tomoatsu MUNE⁴  Yoshihiko YAMADA⁵  Hajime NAWATA⁶  Masao OMURA⁵  Tomoyuki IWASAKI⁵  Yukitaka MIYACHI²  Ryoichi TAKAYANAGI⁷  Tatsuo ISHIZUKA¹  Toshihiko YANASE⁶  Hisahiko SEKIHARA⁵ 

[1] General Internal Medicine, Gifu University School of Medicine;First Department of Internal Medicine, Toho University School of Medicine;Department of Gastroenterology, Yokohama City University Graduate School of Medicine;Department of Endocrinology, Diabetes and Rheumatology, Gifu University School of Medicine;Department of Endocrinology and Metabolism, Yokohama City University Graduate School of Medicine;Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University;Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University

关键词: Dehydroepiandrosterone (DHEA);    Dehydroepiandrosterone sulfate (DHEAS);    Androgen;    Hormone replacement;    Insulin resistance;   

DOI  :  10.1507/endocrj.K05-132

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(43)Cited-By(6)In man, serum concentrations of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) decrease with age after the twenties. For this reason, the decline in DHEA and DHEAS concentrations may be related to the development of some chronic diseases that are prevalent in the older age population. In this study, we evaluate the benefit and safety level of DHEA administration to men as a hormone replacement therapy. Twenty-two healthy Japanese males (age 26-63; mean ± SD, 41.0 ± 10.0 yrs.) received 25 mg DHEA once a day orally in the morning for two weeks. Serum concentrations of steroid hormones and cytokines were measured before and after the DHEA administration. Glucose tolerance and insulin resistance were also assessed before and after the DHEA administration using a 75 g oral glucose tolerance test and homeostasis model assessment (HOMA-R), respectively. Serum DHEA and DHEAS levels were significantly elevated after the DHEA administration for all ages of test subjects. In subjects who were older than 41 yrs. (older group) serum androstenedione and estradiol levels were elevated after the DHEA administration. Significant negative correlations were observed between the serum DHEA concentration and the serum concentration of fasting insulin, HOMA-R, leptin, and high-sensitivity C-reactive protein for all subjects. Daily administration of 25 mg DHEA increased the serum DHEA, DHEAS, androstenedione, and estradiol levels of the subjects of the older group to the same level as that of younger subjects.

【 授权许可】

Unknown