Hormone Replacement Therapy and Vascular Risk Disorders in Adult Hypopituitarism

Endocrine Journal

Hidesuke KAJI²  Kazauo CHIHARA¹  Yasuhiko OKIMURA³  Keiji IIDA¹  Yutaka TAKAHASHI¹ 

[1] Division of Endocrinology/Metabolism, Neurology and Hematology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine;Division of Physiology/Metabolism, University of Hyogo;Department of Basic Allied Medicine, Kobe University School of Medicine

关键词: Adult hypopituitarism;    Vascular risk disorders;    Hormone replacement;    TSH deficiency;    Hyperlipidemia;   

DOI  :  10.1507/endocrj.K06-129

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(24)Cited-By(6)Adult patients with hypopituitarism are treated by the replacement of deficient hormones, although GH has not been substituted until March 2006 in Japan except for clinical trial. This study examines which hormonal status influences the prevalence of vascular risk disorders in hypopituitary adults. A sample of 263 adult patients with hypopituitarism was studied, among whom there were various hormonal status such as no deficiency, treated or untreated deficiency of each pituitary hormone. Analysis of adult patients with hypopituitarism showed that hypertension was more prevalent in the older than in younger patients and in male than in female patients. Hypercholesterolemia and hypertriglyceridemia were more prevalent in patients with TSH deficiency even with thyroxine substitution than those without TSH deficiency. Both obesity and hypertension were less prevalent in patients with treated ACTH deficiency than those without ACTH deficiency. Obesity was more prevalent in patients with treated vasopressin deficiency than those without vasopressin deficiency. These results provide evidence that glucocorticoid substitution in ACTH deficient adults was favorable to prevent obesity and hypertension but that the thyroxine substitution in TSH deficient adults appeared rather insufficient to prevent hyperlipidemia.

【 授权许可】

Unknown