Opposite Effects of Basic Fibroblast Growth Factor on Gonadotropin-Stimulated Steroidogenesis in Rat Granulosa Cells

Endocrine Journal

MAREO YAMOTO¹  TOSHIHIKO SHIKONE¹  RYOSUKE NAKANO¹ 

[1] Department of Obstetrics and Gynecology, Wakayama Medical College

关键词: Granulosa cell;    bFGF;    Steroidogenesis;    FSH;    LH;   

DOI  :  10.1507/endocrj.40.691

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(29)Cited-By(8)In the present study, we examined the effect of basic fibroblast growth factor (bFGF) on gonadotropin-dependent estradiol and progesterone production in cultured rat immature and FSH-primed granulosa cells. Treatment with bFGF alone did not affect the biosynthesis of estradiol and progesterone in immature and FSH-primed granulosa cells. Basic FGF significantly inhibited FSH-induced estradiol and progesterone production in both immature and FSH-primed granulosa cells. In contrast, bFGF exerted a significant stimulatory effect on LH-induced estradiol and progesterone production in FSH-primed granulosa cells. Our finding that bFGF exerts opposite effects on gonadotropin-dependent steroidogenesis suggests that bFGF may play important paracrine and/or autocrine roles in the process of follicular development, ovulation, and subsequent luteinization.

【 授权许可】

Unknown