The effect of estradiol on granulosa cell responses to FSH in women with polycystic ovary syndrome

Reproductive Biology and Endocrinology

Research

Rana F. Shayya¹  Marcus A. Rosencrantz²  Michael V. Homer³  R. Jeffrey Chang⁴ 

[1] Obstetrics and Gynecology, Southern California Permanente Medical Group, 250 Travelodge Drive, 92020, El Cajon, CA, USA;Reproductive Endocrinology and Infertility, Southern California Permanente Medical Group, 6650 Alton Parkway, 92618, Irvine, CA, USA;Reproductive Medicine, University of California, 200 West Arbor Drive MC: 8710, 92103, San Diego, CA, USA;Reproductive Medicine, University of California, 200 West Arbor Drive MC: 8710, 92103, San Diego, CA, USA;9500 Gilman Drive #0633 La Jolla, 92093, San Diego, CA, USA;

关键词: Polycystic ovary syndrome;    Granulosa cell;    Estradiol;    FSH;    Inhibin B;   

DOI  :  10.1186/s12958-017-0230-0

 received in 2017-01-19, accepted in 2017-02-08,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe influence of estradiol (E2) on granulosa cell (GC) function has not been tested clinically in women with polycystic ovary syndrome (PCOS). The objective of this study is to determine if E2 influences GC responses to FSH in women with PCOS.MethodsThis is a two phase, single cohort study conducted over a 2-year period at a single academic center. Nine women with PCOS according to NIH criteria. In Phase 1, FSH stimulation of GC responses as measured by E2 and Inhibin B (Inh B) were assessed before and at 5 and 6 weeks after GnRH agonist administration. In Phase 2, the same protocol was employed with the addition of an aromatase inhibitor (letrozole, LET) administered daily beginning at week 4 for 2 weeks.ResultsIn Phase 1, recovery of FSH, E2 and Inh B from ovarian suppression occurred at 5 and 6 weeks after GnRH agonist injection and preceded resumption of LH and androgen secretion. In Phase 2, hormone recovery after GnRH agonist was characterized by elevated FSH and suppressed E2 levels whereas recovery of LH and androgen levels were unchanged. In Phase 1, FSH stimulated E2 and Inh B responses were unaltered during recovery from ovarian suppression. In Phase 2, E2 and Inh B fold changes after FSH were significantly reduced at weeks 5 (p < 0.04) and 6 (p < 0.01), respectively.ConclusionIn anovulatory women with PCOS, chronic, unopposed E2 secretion may contribute, at least in part, to enhanced ovarian responsiveness to FSH.Trial registrationNCT02389088

【 授权许可】

CC BY   
© The Author(s). 2017