Evaluation of the acute toxicity of limonene epoxide in adult mice

Revista Cubana de Plantas Medicinales

Cardoso de Almeida, Antonia Amanda²  de Souza, Geane Felix³  Mendes de Freitas, Rivelilson²  da Silva Oliveira, Johanssy³  Fonseca de Carvalho, Rusbene Bruno²  Pergentino de Sousa, Damião¹ 

[1] Departamento de Fisiologia da Universidade Federal da Paraíba, Brasil;Universidade Federal do Piauí, Brasil;Faculdade de Medicina,Universidade Federal do Ceará, Brasil

关键词: limonene epoxide;    biochemistry;    hematology;    acute toxicity;   

DOI  :  

学科分类：药理学

来源: Editorial Ciencias Medicas

【 摘 要 】

Introduction: the biodiversity of global flora provides important molecules for the treatment and prevention of various human diseases, but most often their toxicities are not evaluated.Objective:evaluate the toxicity of monoterpenoid limonene epoxidein mice treated acutely with repeated doses (25, 50 and 75 mg/kg) orally on hematological and biochemical parameters.Methods: forty mice divided infour groups (n = 10/group ) were treated orally andacutely with repeated doses and observed for 14 days. The mice were treatedwith limonene epoxide administered at doses of 25, 50 and 75 mg / kg emulsified with 0.05 % Tween 80 dissolved in 0.9 % saline (groupsEL25, EL50 and EL75, respectively)and withvehicle (0.05 % Tween 80, dissolved in 0.9% saline, control group).Results:the treatment caused no deaths or signs of toxicity in the mice treated.Discussion:thus, based on the results obtained from hematological and biochemical studies in mice, it can be suggested that limonene epoxide does not produce anytoxic effect on most of the parameters analyzed, and can be safely used in pre-clinical-assays However, more studies should be conducted to ensure that this derivative of a natural monoterpenecan be safely used in thefood and pharmaceutical industry.

【 授权许可】

Unknown