A Case of Atypical Canine Lymphoma with Oral Mass and Multiple Osteolysis

Journal of Veterinary Medical Science

Masaharu HISASUE⁵  Masaru OKUDA⁴  Takefumi ISHIKAWA⁵  Yoshitaka ENOMOTO²  Ryo TSUCHIYA⁵  Munetsugu OGATA¹  Hiroo MADARAME¹  Sakurako NEO⁵  Takatsugu YAMADA⁵  Takuo SHIDA³  Tetsuro ITO¹  Toshifumi WATANABE¹ 

[1] Veterinary Teaching Hospital, School of Veterinary Medicine, Azabu University;Enomoto Animal Hospital;Department of Veterinary Radiology, School of Veterinary Medicine, Azabu University;Faculty of Agriculture, Yamaguchi University;Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Azabu University

关键词: canine;    lymphoma;    PCR;   

DOI  :  10.1292/jvms.69.977

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(14)Cited-By(4)An 8-year-old female Golden Retriever had an oral mass and lameness. Multiple osteolysis of the systemic skeleton without monoclonal gammopathy was shown on electrophoresis of serum and urine samples. Cytological and histopathological examinations of the oral mass revealed atypical polymorphic cells similar to myeloid cells, and bone marrow aspiration indicated that these abnormal cells also might have invaded the bone marrow. These cells were negative to peroxidase and non-specific esterase staining, and clonal expansion of B lymphocytes could be detected by polymerase chain reaction (PCR) assay for antigen receptor gene rearrangement. The case was diagnosed as atypical lymphoma and treated by multi-drug chemotherapy. On the 142nd day after the first admission, the case had remission and the oral mass and multiple osteolysis were improved.

【 授权许可】

Unknown