Changes in Activities of Enzymes Related to Energy Metabolism in Canine Lymphoma Cells

Journal of Veterinary Medical Science

Makoto BONKOBARA¹  Makoto WASHIZU²  Daigo AZAKAMI¹  Tsukimi WASHIZU¹  Toshiro ARAI³ 

[1] Department of Clinical Pathology, Nippon Veterinary and Animal Science University;Veterinary Medical Teaching Hospital, Nippon Veterinary and Animal Science University;Department of Biochemistry, Nippon Veterinary and Animal Science University

关键词: canine;    lymphoma;    malate dehydrogenase;   

DOI  :  10.1292/jvms.67.615

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(21)Cited-By(2)Alterations in the activities of enzymes related to energy metabolism in canine lymphoma cells were investigated. Cytosolic pyruvate kinase (PK) and mitochondrial malate dehydrogenase (MDH) activities in lymphoma cells were significantly higher than those in lymphocytes obtained from lymph nodes of healthy dogs, whereas cytosolic lactate dehydrogenase (LDH) activity was significantly lower in lymphoma cells. The cytosolic M/L ratio (MDH activity/LDH activity), which is considered to be a good indicator of energy metabolism related to glucose utilization in animal tissues, was significantly higher in lymphoma cells than in the normal lymphocytes.

【 授权许可】

Unknown