Acute and Chronic Regulation of ob m RNA Levels by β3-Adrenoceptor in Obese Yellow KK Mice

Endocrine Journal

TSUNEKAZU UMEKAWA¹  MOTOHARU KONDO¹  TOSHIHIDE YOSHIDA¹  YASUNORI SASAKI²  ATSUSHI ASANO²  AKINORI KOGURE¹  YOSHIKO NAKAMURA²  MASAYUKI SAITO²  NAOKI SAKANE¹ 

[1] First Department of Internal Medicine, Kyoto Prefectural University of Medicine;Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University

关键词: Leptin;    ob gene;    β3-adrenergic receptor agonist;    Diabetes mellitus;    Obesity;   

DOI  :  10.1507/endocrj.45.647

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(27)Cited-By(4)The inhibitory effect of β3-adrenoceptor agonists on the ob gene in brown adipose tissue (BAT) and white adipose tissue (WAT) is now well documented both in vivo in lean animals and in vitro, but the reported effects of β3-adrenoceptor agonists on ob gene expression in obese animals remain controversial. We investigated whether ob gene expression in BAT and WAT is reduced by acute and chronic administrations of a β3-adrenoceptor agonist, CL316, 243 (CL). The ob gene mRNA levels in BAT, perimetric and inguinal WAT of obese Yellow KK mice were about 4-fold higher than those of lean controls. Acute exposure (6 h) to CL decreased ob gene mRNA levels in three fat depots in both animals. Chronic exposure (10 days) to CL also decreased ob gene mRNA levels in BAT, perimetric, and inguinal WAT in both animals. We concluded that acute and chronic regulation by a β3-adrenoceptor agonist suppressed ob gene expression in obese Yellow KK mice and lean cotrols.

【 授权许可】

Unknown