Impaired Guanosine 3', 5'-Cyclic Phosphate Production in Severe Pregnancy-Induced Hypertension with High Plasma Levels of Atrial and Brain Natriuretic Peptides

Endocrine Journal

MASASHI MUKOYAMA¹  HIROSHI ITOH¹  TAKAHIDE MORI²  KAZUWA NAKAO¹  HIROAKI ITOH²  HIDETAKA NANNO²  NORIMASA SAGAWA² 

[1] Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine;Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine

关键词: Atrial natriuretic peptide;    Brain natriuretic peptide;    Guanosine 3';    5'-cyclic phosphate;    Pregnancy-induced hypertension;   

DOI  :  10.1507/endocrj.44.389

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(16)Cited-By(7)To investigate the activation of particulate guanylate cyclase in pregnant women with pregnancy-induced hypertension (PIH), plasma levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and guanosine 3', 5'-cyclic phosphate (cGMP) were measured by radioimmunoassays specific to each substance. Ten normal nonpregnant women, and 30 normal pregnant women, 17 pregnant women with mild PIH and 11 pregnant women with severe PIH in the third trimester were included in this retrospective observational study. The diagnosis and classification of hypertension were carried out according to the technical bulletin (No. 91) of the American College of Obstetricians and Gynecologists. In the pregnant women with mild PIH, plasma cGMP levels as well as ANP and BNP levels were significantly (P<0.05) higher than those in gestational age-matched normal pregnant or nonpregnant women. But in the pregnant women with severe PIH, plasma cGMP levels were significantly lower than those in pregnant women with mild PIH (P<0.05), although plasma ANP and BNP levels were higher than those in pregnant women with mild PIH.

【 授权许可】

Unknown