Glycation Accelerates the Oxidation of Low Density Lipoprotein by Copper Ions

Endocrine Journal

FUMIO UMEDA¹  JUN WATANABE¹  HAJIME NAWATA¹  KUNIHISA KOBAYASHI¹ 

[1] The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University

关键词: Low density lipoprotein;    Oxidation;    Glycation;    Copper ion;   

DOI  :  10.1507/endocrj.42.461

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(27)Cited-By(35)We investigated the in vitro effect of glycation on LDL oxidation. Native LDL (nLDL) was glycated in 0, 5, 10, or 20mM glucose. This glycated LDL (gLDL) was oxidized by 1μM copper ion. Compared to nLDL and gLDL, oxidized gLDL (ogLDL) has a greater negative charge. The thiobarbituric acid reactive substance (TBARS) value of ogLDL increased with the glucose concentration tested during glycation in a dose-dependent manner. OgLDL glycated in 20mM glucose had a significantly higher TBARS level than did oxidized LDL incubated without glucose. In conclusion, LDL glycated in vitro is prone to oxidation. Thus, glycated LDL, which increases in the diabetic state, may contribute to the pathogenesis of atherosclerosis in diabetic patients.

【 授权许可】

Unknown