Glycaemic index and glycaemic load in relation to blood lipids – 6 years of follow-up in adult Danish men and women

Public Health Nutrition

Anne Lene Oxlund¹  Berit Lilienthal Heitmann¹ 

关键词: Diet history interview;    Cholesterol;    Prospective population study;    Prevention;    Public health;   

DOI  :  10.1079/PHN2005916

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

BackgroundCross-sectional studies have suggested an association between glycaemic index (GI) or glycaemic load (GL) and serum lipids. However, no prospective studies have been performed.ObjectiveTo examine whether GI or GL was associated with subsequent changes in serum lipids.DesignProspective study with 6 years of follow-up. Overall dietary GI and GL of each participant were assessed from diet history interviews.SettingPopulation-based study.SubjectsThree hundred and thirty-five healthy men and women aged 35–65 years selected randomly from a larger sample of Danish adults.ResultsIn men GI was directly related to changes in total cholesterol (ΔTC), regression coefficient (β) = 0.0044 (95% confidence interval (CI): 0.0008–0.0081) and GL was positively related to changes in low-density lipoprotein cholesterol (ΔLDL), β = 0.1554 (95% CI: 0.0127–0.2982). Furthermore, the relationship between GL and ΔTC was modified by age, being particularly strong for the younger men (P = 0.02). In women the relationship between GI and ΔLDL was modified by age and was stronger for younger rather than older women (P = 0.01). A tendency for a similar interaction was seen for GI and ΔTC (P = 0.09). Associations between GL and ΔLDL and GL and ΔTC were inverse for women with body mass index ≥ 30 kg m−2 (P = 0.03 and 0.04, respectively).ConclusionsThis is the first study to demonstrate that dietary GI and GL are related to 6-year changes in serum lipid levels. However, associations were weak and generally confined to subgroups.

【 授权许可】

Unknown