Protective Effect of T-588 on Toxic Damage by Serum Deprivation and Amyloid-β Protein in Cultured Neurons

Journal of Pharmacological Sciences

Akemichi Baba¹  Akiko Yamamuro³  Sadaaki Maeda²  Yoshiyuki Sakai¹  Yukio Ago³  Toshio Matsuda³ 

[1] Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University;Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University;Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University

关键词: T-588;    neuronal death;    extracellular signal-regulated kinase;   

DOI  :  10.1254/jphs.92.153

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(13)Cited-By(5)The present study examines the effect of the cognition enhancer (1R)-1-benzo[b]thiophen-5-yl-2-[2-(diethylamino)ethoxy]ethan-1-ol hydrochloride (T-588) on neuronal injury induced by serum deprivation or amyloid-β protein (Aβ). T-588 protected partially against neuronal injury induced by serum deprivation or Aβ in cultured cortical neurons. T-588 did not affect the phosphorylation of extracellular signal-regulated kinase (ERK) in cortical neurons and SH-SY5Y cells. These results suggest that T-588 has a protective effect in neuronal injury models and the effect is not mediated by an ERK signal pathway.

【 授权许可】

Unknown