Expression of Two Novel Cytochrome P450 3A131 and 3A132 in Liver and Small Intestine of Domestic Cats

Journal of Veterinary Medical Science

Tetsuya KOMATSU²  Kouichi HONDA²  Yasuhiro UNO¹  Takeo HIRAGA²  Hiroki TERAOKA²  Akira KUBOTA²  Fumika KOYAMA²  Takio KITAZAWA²  Hiroyuki ASAKURA²  Kei KAWAKAMI² 

[1] Pharmacokinetics and Bioanalysis Center (PBC), Shin Nippon Biomedical Laboratories (SNBL);School of Veterinary Medicine, Rakuno Gakuen University

关键词: carnivore;    cytochrome P450;    domestic cat;    felid;    xenobiotics;   

DOI  :  10.1292/jvms.11-0098

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(16)Cited-By(2)Cytochrome P450 3A (CYP3A) is the major subfamily of CYP, one of the most important metabolizing enzymes for drugs in humans and other mammals. We found two novel CYP3A genes, CYP3A131 and CYP3A132 in domestic cats (Felis catus). Both feline CYP3A proteins consist of 504 deduced amino acids and show high identity with canine CYP3A homologues and those of some artiodactyls. CYP3A131 transcripts were expressed predominantly in liver and small intestine, and to a negligible extent in other tissues, including brain, heart, kidney and lung. CYP3A132 expression was only detected in liver with much lesser amount. These results suggest the possible major role of CYP3A131 in xenobiotic metabolism including first-pass effects in domestic cats.

【 授权许可】

Unknown