Activin A: Autocrine Regulator of Kidney Development and Repair

Endocrine Journal

Itaru KOJIMA¹  Yoshihisa NOJIMA²  Akito MAESHIMA²  Masaaki MIYA²  Keiichiro MISHIMA²  Shin YAMASHITA² 

[1] Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University;Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine

关键词: Activin;    Follistatin;    Renal organogenesis;    Kidney regeneration;   

DOI  :  10.1507/endocrj.KR-113

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(67)Cited-By(4)The research described in this review suggests a novel and important role for activin A in the developmental and repair processes of the kidney (Table 1). The results obtained in these studies indicate that activin A is a negative regulator of kidney development and plays an essential part in kidney diseases, such as acute renal failure or renal fibrosis. It is also possible that activin A is a key player in the pathophysiological processes of other kidney diseases, such as congenital urogenital abnormalities, renal cystic disease and renal cell carcinoma. Activin A is thus a potential target for therapeutic interventions in kidney diseases. To address this issue, more detailed analysis on the regulation of activin production, modulation of activin activity and activin target genes is required.

【 授权许可】

Unknown