Randomized clinical trial comparing different iodine interventions in school children

Public Health Nutrition

Qinlan Zhang¹  Kevin M Sullivan¹  Jinkou Zhao¹  Zhigao Chen¹  Fujie Xu¹  Glen F Maberly¹  Li Shang¹  Aixiang Xu¹  Yuan Gao¹ 

关键词: Iodine deficiency disorders;    Randomized trial;    Intervention;    Iodized salt;    Iodized oil;    Goitre;    Thyroid volume;   

DOI  :  10.1017/S1368980099000221

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

ObjectiveThe purpose of this trial was to compare three different iodine interventions.DesignSchool children aged 8–10 years were randomized into one of three groups: group A was provided with iodized salt by researchers with an iodine concentration of 25 ppm; group B purchased iodized salt from the market; and group C was similar to group B with the exception that they were given iodized oil capsules containing 400 mg iodine at the beginning of the study. Salt iodine content was measured bimonthly for 18 months and indicators of iodine deficiency were measured at baseline and 6, 9, 12 and 18 months after randomization.ResultsThe prevalence of abnormal thyroid volumes, based on the World Health Organization (WHO) body surface area reference > 97th percentile, was 18% at baseline and declined to less than 5% by 12 months in groups A and C, and to 9% after 18 months in group B. Results for goitre by palpation were similar. The median urinary iodine was 94 μgl−1 at baseline and increased in all groups to > 200 μgl−1 at the 6-month follow-up.ConclusionsIn this population of school children with initially a low to moderate level of iodine deficiency, the group receiving salt with 25 ppm (group A) was not iodine deficient on all indicators after 18 months of study. When the iodine content of the salt varied, such as in group B, by 18 months thyroid sizes had not yet achieved normal status.

【 授权许可】

Unknown