Hepatitis B vaccination and injecting drug users

British Journal of General Practice

John Budd¹  Rob Elton¹  Roy Robertson¹ 

[1] Edinburgh Drug Addiction Study

关键词: hepatitis B;    hepatitis C;    HIV;    vaccination;    IV drug users;    immunology;    serology;   

DOI  :  

学科分类：卫生学

来源: Royal College of General Practitioners

【 摘 要 】

This study seeks to test the feasibility of vaccinating injecting drug users for hepatitis B in primary care and to identify predictors of poor immune response. Two hundred and seventy-five injecting drug users were identified from the case notes of a large general practice in an area of high multiple deprivation in northwest Edinburgh and, where appropriate, offered hepatitis B vaccination followed by a post-vaccination serological test. We concluded that hepatitis B vaccination of drug users in primary care is both feasible and effective. This study was unable to identify a group at risk of vaccine failure, however, it found post-vaccination serological testing to be problematic and potentially misleading. Therefore, we would not recommend its routine use in a primary care setting. Significantly, prolonged primary courses were not associated with reduced efficacy. The findings indicate that an appropriate vaccination schedule for primary care should be flexible to maximise compliance.

【 授权许可】

Unknown