Prophylactic Efficacy of Desmopressin Acetate for Diabetes Insipidus after Hypophysectomy in the Dog

Journal of Veterinary Medical Science

Yasushi HARA²  Yukihiro FUJITA²  Hiroyuki MASUDA²  Daisuke HASEGAWA¹  Yoshinori NEZU²  Masahiro TAGAWA²  Takahiro TAODA² 

[1] Division of Veterinary Radiology, School of Veterinary Medicine, Nippon Veterinary and Animal Science University;Division of Veterinary Surgery, Nippon Veterinary and Animal Science University

关键词: canine;    desmopressin acetate;    hypophysectomy;   

DOI  :  10.1292/jvms.65.17

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(21)Cited-By(6)The prophylactic efficacy of desmopressin acetate (DDAVP) on diabetes insipidus (DI) after hypophysectomy was investigated in the dog. In the control group, hypernatremia with a plasma level of 155 mEq/l or higher persisted for 12 hr from the 4th to the 16th hour after hypophysectomy, and symptoms of DI developed within five days after surgery. In the DDAVP treatment group, these changes were not observed, showing that administration of DDAVP (4 μg, instillation, twice daily) effectively prevented hypernatremia that develops immediately after surgery and DI-like symptoms that persists for about one week after surgery.

【 授权许可】

Unknown