Identification and Sequence Analysis of the Marek's Disease Virus Serotype 2 Gene Homologous to the Herpes Simplex Virus Type 1 UL52 Protein

Journal of Veterinary Medical Science

Chieko KAI¹  Takeshi MIKAMI¹  Yoshihiro IZUMIYA¹  Kazuya NAKAMURA¹  Takayuki MIYAZAWA¹  Hyung-Kwan JANG¹  Jin-Shun CAI¹  Kentaro KATO¹  Yorihiro NISHIMURA¹  Yoshinori TSUSHIMA¹ 

[1] Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

关键词: Marek's disease virus serotype 2;    transcript;    UL52;   

DOI  :  10.1292/jvms.61.683

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(24)Cited-By(1)The gene of Marek's disease virus serotype 2 (MDV2) homologous to the UL52 gene of herpes simplex virus type 1 (HSV-1) was identified and characterized. The MDV2 UL52 homologous gene encodes 1, 071 amino acids with a molecular weight of 118.7 kDa, which includes putative metal-binding site and overlapping region with the UL53 homologous gene. Although a putative polyadenylation signal sequence was found in the downstream of the MDV2 UL52 gene, a MDV2 UL52 DNA probe reacted only with the polycistronic 6.3 kb transcript, representing the UL52 and the downstream genes of UL53 and UL54. Transcriptional pattern of this region of MDV2 was somewhat different from corresponding regions of HSV-1 and infectious laryngotracheitis virus.

【 授权许可】

Unknown