Toxicity of nitric oxide and peroxynitrite to bacterial pathogens of fish

Diseases of Aquatic Organisms

Juan J. Campos-Pérez¹  Christopher J. Secombes¹  Anthony E. Ellis¹ 

关键词: SNAP;    SIN-1;    Nitric oxide;    Peroxynitrite;    Renibacterium salmoninarum;    Aeromonas salmonicida;    Yersinia ruckeri;   

DOI  :  10.3354/dao043109

学科分类：生物科学（综合）

来源: Inter-Research

【 摘 要 】

ABSTRACT: The inhibitory effect of the nitric oxide (NO) donor S-nitroso-acetyl-penicillamine (SNAP) and the NO and O₂^- donor 3-morpholino-sydnonimine hydrochloride (SIN-1) was tested in a cell-free assay. Strains of the bacterialfish pathogens Aeromonas salmonicida, Renibacterium salmoninarum and Yersinia ruckeri were exposed to different concentrations of the NO donors for 24 h. The results showed that NO possesses inhibitory properties, while peroxynitritehad no effect. However, when SIN-1 was used in combination with superoxide dismutase (SOD) alone or with catalase, an inhibitory effect comparable to that caused by SNAP was seen. The implications of these results are discussed.

【 授权许可】

Unknown