Impact of Artemisinin-Based Combination Therapy on Falciparum Malaria in Urban Kolkata: A Clinic-Based Report

Japanese Journal of Infectious Diseases

Ardhendu K. Maji¹  Pratip K. Kundu¹  Pabitra Saha¹  Soma Dutta¹  Nandita Basu²  Dilip K. Bera¹  Swagata Ganguly¹ 

[1] Deparment of Microbiology, Calcutta School of Tropical Medicine;Calcutta School of Tropical Medicine

关键词: ACT;    Plasmodium falciparum;    Plasmodium vivax;    Kolkata;    P. falciparum proportion;   

DOI  :  10.7883/yoken.JJID.2014.284

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

References(12)Cited-By(2)In India, artemisinin-based combination therapy (ACT; specifically artesunate + sulfadoxine-pyrimethamine) has been implemented for uncomplicated falciparum malaria since 2010. But for vivax malaria drug policy remained unchanged i.e., chloroqine and primaquine. We observed the impact of this intervention in urban Kolkata by analyzing data from the Malaria Clinic from 2001 to 2013. In Kolkata, we observed that Plasmodium vivax was perennial, whereas P. falciparum infection was seasonal. Before ACT implementation, the proportion of P. falciparum was as high as 50% and it steadily decreased during 4 successive years post intervention. No change was observed in the number of P. vivax cases. ACT may be an effective measure in reducing falciparum malaria cases. Artemisinin-derivative combination therapies should be explored in vivax malaria to reduce the overall burden of malaria.

【 授权许可】

Unknown