Effect of six-month lifestyle intervention on adiponectin, resistin and soluble tumor necrosis factor-α receptors in obese adolescents

Endocrine Journal

Eliseo Ruiz-Bedolla³  Omar Josué Saucedo-Ramírez⁴  José Alfredo Pérez-Ontiveros¹  Blanca Estela del-Río-Navarro⁴  Enrique Hong⁵  Fengyang Huang¹  Santiago Villafaña²  Guadalupe Bravo⁵  Patrick Mailloux-Salinas⁵ 

[1] Laboratory of Pharmacology and Toxicology, Hospital Infántil de México Federico Gómez (HIMFG), Mexico City 06720, Mexico;Superior School of Medicine, National Polytechnic Institute, Mexico City 11340, Mexico;Center Laboratories, HIMFG, Mexico City 06720, Mexico;Department of Allergy, HIMFG, Mexico City 06720, Mexico;Department of Pharmacobiology, Centro de Investigación y de Estudio Avanzados del Instituto Politécnico Nacional, Mexico City 14330, Mexico

关键词: Adiponectin;    Resistin;    Tumor necrosis factor-α receptor;    Life-style intervention;    Obese adolescents;   

DOI  :  10.1507/endocrj.EJ14-0157

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(44)Cited-By(3)The aim of this study was to evaluate the effect of a six-month lifestyle intervention on adiponectin, resistin, and two soluble forms of tumor necrosis factor-α receptor (sTNFR) in obese adolescents.A total of 54 obese adolescents aged 10 to 16 years completed the program.Twenty-four adolescents with normal weight at baseline were used as a control group.Our results demonstrated that obese adolescents had abnormal lipid profile, homeostasis model assessment (HOMA) index, adiponectin level (5.6±2.7 vs. 7.6±2.9 μg/mL, p=0.005) as well as resistin level (31.0±9.0 vs. 24.3±8.5 ng/mL, p=0.003), whereas levels of both sTNFRs were similar to those in normal weight subjects.After the six-month lifestyle intervention, obese adolescents had a slight but significant drop in standard deviation score-body mass index (SDS-BMI), a significant decrease in waist circumference, total cholesterol, triglycerides, HOMA index, as well as resistin, and a significant increase in adiponectin and high-density lipoprotein-cholesterol.In adolescents without decreased SDS-BMI, no change was observed in adipokines.Changes in adiponectin correlated negatively with changes in waist circumference (r=-0.275, p=0.044).Changes in resistin correlated positively with changes in triglycerides (r=0.302, p=0.027).The study demonstrated the increase of resistin and the decrease of adiponectin in obese adolescents.Lifestyle intervention improved adipokine abnormalities in obese subjects.

【 授权许可】

Unknown