Adiponectin/resistin levels and insulin resistance in children: a four country comparison study

International Journal of Pediatric Endocrinology

Marwah Abdalla⁶  Eiichi Ishii¹  Leonardo Pinelli²  Anita Morandi²  Supawadee Likitmaskul⁴  Isao Saito⁵  Richard J Deckelbaum³  Koji Takemoto¹ 

[1] Department of Pediatrics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan;Centre for Pediatric Diabetes, Clinical Nutrition and Obesity, U.L.S.S. 20 and University of Verona, Verona, Italy;Department of Pediatrics, Columbia University, New York, USA;Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand;Basic Nursing and Health Science, Ehime University Graduate School of Medicine, Toon, Japan;Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, USA

关键词: Metabolic syndrome;    Insulin resistance;    Resistin;    Adiponectin;   

Others  :  1133549
DOI  :  10.1186/1687-9856-2015-2

 received in 2014-08-22, accepted in 2014-12-16,  发布年份 2015

【 摘 要 】

Background

There are few reports on the effects of ethnicity or gender in the association between adipocytokines and insulin resistance in children of different ages. This study assessed associations between serum concentrations of adiponectin/resistin and parameters of insulin resistance in children from 4 different countries.

Methods

A total of 2,290 children were analyzed in this study; each was from one of 4 different countries (Japan, Thailand, Italy and USA), and grouped according to age (8–11 years old in Group 1 and 12–15 years old in Group 2).

Results

Adioponectin was higher in female than in male children, and in Group 1 than in Group 2. Generally, adiponectin was lower in Asian as compared to Italian and American children. These tendencies remained even after adjustment for body mass index (BMI) or waist circumstance (WC). Among older children (Group 2), resistin was higher in female than in male children. Significant correlations by non-parametric univariate correlation coefficients and Spearman’s rank correlation coefficients were found between adiponectin and homeostasis model assessment of insulin resistance (HOMA-IR), and fasting serum insulin levels in young Japanese, Italian, and American female children(p < 0.01, p < 0.05, p < 0.05, respectively). Correlations between serum adiponectin and HOMA-IR were also found among older male Italian, American, and Thai children (p < 0.05, p < 0.001, p < 0.001, respectively). In multiple regression analysis by forced entry method, adiponectin correlated with HOMA-IR in Italian and American male children, and in all older female children regardless of country of origin. There was no correlation between resistin and markers of insulin resistance in children from any of the countries.

Conclusions

We conclude that serum adiponectin concentrations are lower in Asian as compared to Italian and American children, and that adiponectin but not resistin contributes to differences in markers for insulin resistance in children from different populations.

【 授权许可】

   
2015 Takemoto et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

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