Changed adipocytokine concentrations in colorectal tumor patients and morbidly obese patients compared to healthy controls

BMC Cancer

Research Article

Nadine Huber¹  Uwe Knippschild¹  Juliane Fassler¹  Anna Maria Wolf¹  Doris Henne-Bruns¹  Pengfei Xu¹  Andreas Hillenbrand¹  Hubert Schrezenmeier²  Markus Templin³ 

[1]Department of General and Visceral Surgery, University Hospital of Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany

[2]Institute of Clinical Tranfusion Medicine and Immunogenetics, Helmholtzstr. 10, 89081, Ulm, Germany

[3]NMI at the University of Tuebingen, Markwiesenstr. 55, 72770, Reutlingen, Germany

关键词: Adipokine;    Adipocytokine;    Cytokine;    Colorectal cancer;    Morbid obesity;    Adiponectin;    Leptin;    Resistin;   

DOI  :  10.1186/1471-2407-12-545

 received in 2012-04-01, accepted in 2012-11-20,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundObesity has been associated with increased incidence of colorectal cancer. Adipose tissue dysfunction accompanied with alterations in the release of adipocytokines has been proposed to contribute to cancer pathogenesis and progression. The aim of this study was to analyze plasma concentrations of several adipose tissue expressed hormones in colorectal cancer patients (CRC) and morbidly obese (MO) patients and to compare these concentrations to clinicopathological parameters.MethodsPlasma concentrations of adiponectin, resistin, leptin, active plasminogen activator inhibitor (PAI)-1, monocyte chemotactic protein (MCP)-1, interleukin (IL)-1 alpha, and tumor necrosis factor (TNF)-alpha were determined in 67 patients operated on for CRC (31 rectal cancers, 36 colon cancers), 37 patients operated on for morbid obesity and 60 healthy blood donors (BD).ResultsCompared to BD, leptin concentrations were lowered in CRC patients whereas those of MO patients were elevated. Adiponectin concentrations were only lowered in MO patients. Concentrations of MCP-1, PAI-1, and IL-1 alpha were elevated in both CRC and MO patients, while resistin and TNF-alpha were similarly expressed in MO and CRC patients compared to BD. Resistin concentrations positively correlated with tumor staging (p<0.002) and grading (p=0.015) of rectal tumor patients.ConclusionsThe results suggest that both MO and CRC have low-grade inflammation as part of their etiology.

【 授权许可】

CC BY   
© Hillenbrand et al.; licensee BioMed Central Ltd. 2012