A pathological study of the salivary glands of rabid dogs in thePhilippines

Journal of Veterinary Medical Science

Kazunori KIMITSUKI²  Hassadin BOONSRIROJ²  Nozomi SHIWA²  Chun-Ho PARK²  Harumi SHINOZAKI²  Naoto TANAKA²  Daria Llenaresas MANALO¹  Taichi SHIMATSU²  Yurika TAKAHASHI²  Satoshi INOUE³ 

[1] Veterinary Research Department, Research Institute for Tropical Medicine, Department of Health, 9002 Research Drive, Filinvest Corporate City, Alabang, Muntinlupa City 1781, Philippines;Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, 23�?35�?1 Higashi, Towada, Aomori 034�?8628, Japan;Department of Veterinary Science, National Institute of Infectious Diseases, Toyama 1�?23�?1, Shinjuku-ku, Tokyo 162�?8640, Japan

关键词: histopathology;    Philippines;    rabid dog;    salivary gland;   

DOI  :  10.1292/jvms.15-0308

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(36)Cited-By(3)Rabies is a zoonotic disease caused by the rabies virus. While the salivary glands areimportant as exit and propagation sites for the rabies virus, the mechanisms of rabiesexcretion remain unclear. Here, we investigated the histopathology of the salivary glandsof rabid dogs and analyzed the mechanism of excretion into the oral cavity. Mandibular andparotid glands of 22 rabid dogs and three control dogs were used. Mild to moderatenon-suppurative sialadenitis was observed in the mandibular glands of 19 of the 22 dogs,characterized by loss of acinar epithelium and infiltration by lymphoplasmacytic cells.Viral antigens were detected in the mucous acinar epithelium, ganglion neurons andmyoepithelium. Acinar epithelium and lymphocytes were positive for anti-caspase-3antibodies and TUNEL staining. In contrast, no notable findings were observed in theductal epithelial cells and serous demilune. In the parotid gland, the acinar cells,myoepithelium and ductal epithelium all tested negative. These findings confirmed the paththrough which the rabies virus descends along the facial nerve after proliferation in thebrain to reach the ganglion neurons of the mandibular gland, subsequently traveling to theacinar epithelium via the salivary gland myoepithelium. Furthermore, the observation thatnerve endings passing through the myoepithelium were absent from the ductal systemsuggested that viral proliferation and cytotoxicity could not occur there, ensuring thatsecretions containing the virus are efficiently excreted into the oral cavity.

【 授权许可】

Unknown