Follicle sinus complexes (FSCs) in muzzle skin as postmortem diagnostic material of rabid dogs

The Journal of Veterinary Medical Science

Nozomi SHIWA¹  Kazunori KIMITSUKI²  Chikage NAKAJIMA³ 

[1] Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, 23-35-1, Higashi, Towada, Aomori 034-8628, Japan;Department of Veterinary Science, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan;Veterinary Research Department, Research Institute for Tropical Medicine, Department of Health, 9002 Research Drive, Filinvest Corporate City, Alabang, Muntinlupa City 1781, Philippines

关键词: follicle-sinus complex (FSC);    Merkel cell;    post-mortem diagnosis;    rabid dog;   

DOI  :  10.1292/jvms.18-0519

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Recently, we reported that follicle-sinus complexes (FSCs) in the muzzle skin are useful for postmortem diagnosis of rabid dogs. Here, we compared the sensitivity and specificity of detecting the viral antigen in the brain and FSCs of 226 suspected rabid dogs, and assessed whether the FSC harbored the virus genome and particles. The viral antigen was detected in 211 of 226 samples with 100% sensitivity and specificity. Viral RNA and particles were observed in the cytoplasm of Merkel cells (MCs). These results suggest that MCs are targets of virus infection and FSCs are useful material for diagnosing rabies.

【 授权许可】

Unknown