Association of serum YKL-40 levels with urinary albumin excretion rate in young Japanese patients with type 1 diabetes mellitus

Endocrine Journal

Akio Kuroda¹  Tetsuyuki Yasuda³  Keisuke Kosugi²  Mitsuyoshi Takahara³  Naoto Katakami³  Fumie Sakamoto³  Kazuyuki Miyashita³  Munehide Matsuhisa¹  Hideaki Kaneto³  Iichiro Shimomura³ 

[1] Diabetes Clinical Research and Development Center, Tokushima University, Tokushima 770-8503, Japan;Department of Internal Medicine, Osaka Police Hospital, Osaka 543-0035, Japan;Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita 565-0871, Japan

关键词: YKL-40;    Type 1 diabetes;    Albuminuria;    Diabetic retinopathy;   

DOI  :  10.1507/endocrj.EJ12-0238

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(27)Cited-By(8)YKL-40 is a marker of inflammation and endothelial dysfunction, both of which play important roles in the progression of diabetic complications.However, little information has been obtained about serum YKL-40 levels in type 1 diabetic patients. We evaluated YKL-40 levels and its association with diabetic micro- and macroandgiopathy in 131 young Japanese type 1 diabetic patients without advanced diabetic complications (aged 24.7±5.9 years) and 97 age- and gender-matched healthy controls.YKL-40 levels were significantly elevated in type 1 diabetic patients than in healthy controls (median (range) 46.4 (20.3-136.7) and 52.3 (21.4-274.1) ng/mL, respectively, p = 0.003).There was a significant positive association between YKL-40 levels and urinary albumin creatinine ratio (UACR) (r = 0.226, p = 0.013).Furthermore, a multivariate regression analysis demonstrated that YKL-40 levels were a determinant of UACR independently of conventional risk factors.In addition, YKL-40 levels were significantly higher in participants with diabetic retinopathy compared to those without it (median (range) 55.5 (23.3-274.1) and 50.3 (21.4-237.4) ng/mL, respectively, p = 0.039).Serum YKL-40 levels were elevated in type 1 diabetic patients and associated with increasing level of albuminuria.YKL-40 could be a predictor to assess the risk of diabetic microangiopathy in the early stage in type 1 diabetic patients.

【 授权许可】

Unknown