The degree of radiation-induced DNA strand breaks is altered by acute sleep deprivation and psychological stress and is associated with cognitive performance in humans

Sleep

von Scheven, Gudrun^2¹  Feiveson, Alan^1²  Moreno-Villanueva, Maria^1,2³ 

[1] Department of Biology, Molecular Toxicology Group, University of Konstanz, Konstanz, Germany^2;Department of Psychiatry, Division of Sleep and Chronobiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA^3;National Aeronautics and Space Administration, Johnson Space Center, Houston, TX^1

关键词: DNA strand breaks;    Psychomotor Vigilance Test performance;    sleep deprivation;    psychological stress;    individual differences;    biomarkers;    radiation;    Trier Social Stress Test;   

DOI  :  10.1093/sleep/zsy067

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Study ObjectivesSleep deprivation is associated with impaired immune responses, cancer, and morbidity and mortality, and can degrade cognitive performance, although individual differences exist in such responses. Sleep deprivation induces DNA strand breaks and DNA base oxidation in animals, and psychological stress is associated with increased DNA damage in humans. It remains unknown whether sleep deprivation or psychological stress in humans affects DNA damage response from environmental stressors, and whether these responses predict cognitive performance during sleep deprivation.

【 授权许可】

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