PLASMONIC MATERIAL BASED ON SILVER COLLOID ANDZn-METALLOPORPHYRIN FOR DRUG DETECTION OFp-AMINOSALICYLIC ACID

Digest Journal of Nanomaterials and Biostructures

L. Salageanu¹ 

关键词: Silver colloid;    Zn-metalloporphyrin;    P-aminosalicylic acid detection;    AFM;    UV-vis spectroscopy;   

DOI  :  

学科分类：生物技术

来源: Institute of Materials Physics

【 摘 要 】

Para-aminosalicylic acid is still widely used for the efficient treatment of tuberculosisalthough it is known to cause severe adverse side-effects to the human body. This workpresents a simple and efficient spectrophotometric method for PAS detection in theconcentration range of medical relevance useful both for pharmaceutical and for medicalcontrol. The UV-vis investigations were focused on a comparison of sensing activity ofPAS using solely silver nanoparticles or 5,10,15,20-tetrakis-(4-aminophenyl)-porphyrin-Zn(II) or the hybrid material generated between them. The best and accurate detectionresults of PAS, in the medical relevance window (0.1-30μg/mL), were obtained by usingthe hybrid material.

【 授权许可】

Unknown