MCBS (Molecular and Cellular Biomedical Sciences) | |
Cytotoxic Activity of Methoxy-4’amino Chalcone Derivatives Against Leukemia Cell Lines | |
Jumina Jumina^31  Arina Novilla^12  Indwiani Astuti^23  Mustofa Mustofa^24  | |
[1] Doctoral Program, Faculty of Chemistry, Gadjah Mada University, Yogyakarta^4;Doctoral Program, Faculty of Medicine, Gadjah Mada University, Yogyakarta^1;Faculty of Chemistry, Gadjah Mada University, Yogyakarta^3;Faculty of Medicine, Gadjah Mada University, Yogyakarta^2 | |
关键词: anticancer; chalcone derivatives; methoxy-4’-amino chalcone; leukemia; cytotoxic; selectivity; | |
DOI : 10.21705/mcbs.v3i1.44 | |
学科分类:生理学与病理学 | |
来源: Cell and BioPharmaceutical Institute | |
【 摘 要 】
Background: Chemotherapy is a common treatment for leukemia as well as in other cancer treatment. The lack of tumor selectivity and development of multi-drug resistance by chemotherapy caused the development of new strategy in cancer treatment become a pressing need. This study was performed to evaluate the anticancer activity and selectivity of seven derivatives of chalcones against K562 and HL-60 leukemia cell lines. Materials and Methods: The cytotoxicity of chalcone’s seven derivatives (compound 1-7) was tested by using MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxyme-thoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) method. The percentage of cell mortality data was calculated then the IC50 was analyzed using probit analysis (SPSS 17). The selectivity index (SI) then calculated from IC50 ratio of normal lymphocyte cells and cancerous cells line (HL-60 and K562). Results: The IC50 of almost all seven tested compounds were lower in HL-60 cell lines than K562 cell lines, except for Compound 7. The number and position of methoxy groups in chalcone derivatives influenced the anticancer and cancer selectivity of chalcone derivatives. Conclusion: The results revealed that the number and position of methoxy groups in chalcone derivatives influenced the anticancer and cancer selectivity of chalcone derivatives.
【 授权许可】
CC BY-NC
【 预 览 】
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RO201910281489896ZK.pdf | 3441KB | download |