Synthesis of Chiral Chalcone Derivatives Catalyzed by the Chiral Cinchona Alkaloid Squaramide

Molecules

Dandan Xie¹  Ying Xie¹  Yan Ding²  Jian Wu²  Deyu Hu¹ 

[1] State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang 550025, China;

关键词: chalcone derivatives;    enantioselective catalysis;    chiral cinchona alkaloidsquaramides;    addition reaction;   

DOI  :  10.3390/molecules191219491

来源: mdpi

【 摘 要 】

An effective method has been developed for the preparation of novel chiral chalcone derivatives under mild conditions from the easily accessible starting materials nitromethane and chalcone derivatives 2. The corresponding products were obtained in moderate yields with excellent enantioselectivities (up to 99%).

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.