Optical irradiation of cytostatics: photoproducts characterization and tests on rabbit eye pseudotumors

Proceedings of the Romanian Academy Series A-Mathematics Physics Technical Sciences Information Science

Adriana SMARANDACHE¹ 

关键词: cytostatics;    fluorescence;    FTIR;    multidrug resistance;    optical irradiation;    pyridine derivative;    UV/VIS absorption spectroscopy;    eye pseudotumor.;   

DOI  :  

学科分类：计算机科学（综合）

来源: Editura Academiei Romane

【 摘 要 】

This is a review about exposure of drugs solutions to uncoherent and laser radiation inorder to induce changes in drugs’ molecules and to generate photoproducts that alone or in mixtureshave photo-enhanced activity. This could be a way to combat the failure of treatments whenmultidrug resistance is acquired by microorganisms or tumors. The structural modifications inducedby optical radiation on cytostatic compounds were explored by optical absorption, fluorescence, andFourier transform infrared spectroscopy. Results on 5-flurouracil, alongside with a new synthesizedpyridine derivative (BG1120) are detailed. The effects of photoproducts mixtures on inducedpseudotumors in rabbit eyes were estimated with respect to the effects on unirradiated compounds.The irradiation of the eye conjunctiva in which was injected unirradiated parent compound appearedto be more efficient in tumor’s remission than the simple treatment of the eye with unirradiatedcompound, only. The increase of tumor cells membrane permeability may be responsible for theobtained practical results.

【 授权许可】

Unknown