Effect of sublingual immunotherapy on platelet activity in children with allergic rhinitis

Revista Brasileira de Otorrinolaringologia

Chen, Yanqiu¹  Zhou, Lifeng² 

[1] Guangzhou Medical College, Guangzhou, China;Sun Yat-sen University (Northern Campus), School of Public Health, Department of Nutrition, Guangzhou, China

关键词: Allergic rhinitis;    Platelet activation;    Sublingual immunotherapy;    Platelet Factor-4;    Beta-Thromboglobulin.;   

DOI  :  10.1016/j.bjorl.2016.03.006

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

Introduction: The role of platelet activation in allergic inflammation is receiving increasing attention. Sublingual immunotherapy for allergic rhinitis can modify the immunological process to an allergen, rather than simply treating symptoms.Objective: The aim of this study was to explore the role of platelet activation during sublingual immunotherapy in children with allergic rhinitis.Methods: Forty-two House Dust Mite - sensitized children with allergic rhinitis were enrolled and received House Dust Mite allergen extract for sublingual immunotherapy or placebo. Serum of different time points during treatment was collected and used for detection of Platelet Factor-4 and Beta-Thromboglobulin concentration by Enzyme-Linked Immuno Sorbent Assay.Results: Our data showed decreased expression of Platelet Factor-4 and Beta-Thromboglobulin protein after one year's sublingual immunotherapy. In addition, the decrease of symptom scores and serum Platelet Factor-4 and Beta-Thromboglobulin protein concentrations was positively related.Conclusion: During sublingual immunotherapy, platelet activation was inhibited significantly. Our results might indicate that inhibition of platelet activation within the systemic circulation is an important mechanism during sublingual immunotherapy.

【 授权许可】

CC BY