Quality of life improvement after a three-year course of sublingual immunotherapy in patients with house dust mite and grass pollen induced allergic rhinitis: results from real-life

Health and Quality of Life Outcomes

Research

Silviya Mihaylova Novakova¹  Maria Toncheva Staevska²  Plamena Ivanova Novakova²  Maria Stoykova Bratoycheva³  Nina Mihaylova Musurlieva³  Manuela Dimitrova Yoncheva⁴  Valeri Dimitrov Tzekov⁵  Dimitar Georgiev Nicolov⁵ 

[1] Allergy Unit of Internal Consulting Department, University hospital St. George, “Peshtersko shosse” 66, Plovdiv, Bulgaria;Clinic of Allergy and Asthma, Sofia Medical University, “Georgi Sofiiski”1, Sofia, Bulgaria;Faculty of Public Health, Department of Social Medicine and Public Health, Medical University-Plovdiv, “Vasil Aprilov”15A, Plovdiv, Bulgaria;Internal Consulting Department, University hospital “St. George”, “Peshtersko shosse” 66, Plovdiv, Bulgaria;Medical Faculty, The Second Internal Department, Medical University-Plovdiv, “Vassil Aprilov”15A, Plovdiv, Bulgaria;

关键词: Allergic rhinitis;    Quality of life;    Sublingual immunotherapy;    House dust mite;    Grass pollen;    Real life;    Sensitization;   

DOI  :  10.1186/s12955-017-0764-z

 received in 2017-03-27, accepted in 2017-09-24,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundAlong with its high prevalence, the burden of allergic rhinitis rests upon the serious impact on quality of life of patients. Allergic rhinitis is associated with impairments in daily activities, work and school performance, and practical problems. Patients suffer from sleep disorders and emotional problems. Тhe advantages of sublingual immunotherapy on quality of life have only recently begun to emerge. The objective of this prospective real-life study was to evaluate the effect of a three-year course of sublingual immunotherapy with house dust mite (HDM) and grass pollen extracts on quality of life in adults with allergic rhinitis.MethodsA total number of 191 adult patients [105 (54,979%) men; mean age 27.3 years (SD-6.14)] with moderate to severe allergic rhinitis and clinically relevant sensitization to house dust mites or grass pollen were prospectively evaluated in the course of management of their disease. Health-related quality of life was assessed by Rhinoconjunctivitis Quality of Life Questionnaire at baseline and after three-year course of sublingual immunotherapy.ResultsThe mean overall Qol score assessed at baseline and at the end of the third year of treatment decreased significantly in patients treated with HDM extract (from 2.95 to 0.76) as well as with Grass pollen extract (from 2.83 to 1.22) (р < 0.001). The improvements in treated with HDM extract were as followed: activities – 3.52 to 0.68; sleep- 2.48 to 0.31; general problems – 1.79 to 0.49; practical problems – 3.57 to 0.68; nasal symptoms – 3.91 to 0.74; eye symptoms – 2.92 to 0.39; emotions – 3.03 to 0.39. The improvements in grass pollen group were: activities – 3.68 to 1.69; sleep- 1.85 to 0.84; general problems – 1.74 to 0.97; practical problems – 3.52 to 1.37; nasal symptoms – 3.72 to 1.57; eye symptoms – 3.58 to 1.3; emotions – 2.48 to 1.19.ConclusionOur study conducted in real life provided evidence that a three-year course of SLIT with HDM extract as well as with grass pollen extract significantly increased QoL in patients with allergic rhinitis.

【 授权许可】

CC BY   
© The Author(s). 2017