Regulation of membrane dynamics by Parkinson’s disease-associated genes

Journal of genetics

CHANGXU CUI^1¹  TSUYOSHI INOSHITA^1² 

[1] Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan^2;Department of Research for Parkinson’s Disease, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan^1

关键词: soluble NSF-attachment protein receptor;    phosphoinositide;    autophagy;    retromer;    Rab GTPase;    endocytosis;    synaptic vesicle;   

DOI  :  

学科分类：生物科学（综合）

来源: Indian Academy of Sciences

【 摘 要 】

Parkinson’s disease (PD), the second most common neurodegenerative disease after Alzheimer’s disease, develops sporadically, and its cause is unknown. However, 5–10% of PD cases are inherited as monogenic diseases, which provides a chance to understand the molecular mechanisms underlying neurodegeneration. Over 20 causative genes have already been identified and arebeing characterized. These PD-associated genes are broadly classified into two groups: genes involved in mitochondrial functions and genes related to membrane dynamics such as intracellular vesicle transport and the lysosomal pathway. In this review, we summarize the latest findings on the mechanism by which members of the latter group of PD-associated genes regulate membrane dynamics, and we discuss how mutations of these genes lead to dopaminergic neurodegeneration.

【 授权许可】

CC BY