Preclinical PET tracers for the evaluation of sarcomas: understanding tumor biology

American Journal of Nuclear Medicine and Molecular Imaging

Ronnie Sebro³  Ian R Sigal⁴ 

[1] Department of Epidemiology and Biostatistics, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA;Department of Genetics, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA;Department of Orthopedic Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA;Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA

关键词: PET;    sarcoma;    amino acid PET tracers;    nucleoside PET tracers;    hypoxia imaging;   

DOI  :  

学科分类：过敏症与临床免疫学

来源: e-Century Publishing Corporation

【 摘 要 】

Sarcomas are rare tumors of mesenchymal origin. Sarcomas display significant histological heterogeneity, resulting in significant imaging heterogeneity. 18F-FDG PET has is increasingly used for the evaluation, staging and surveillance of patients with sarcomas. 18F-FDG PET maximum SUV has been shown to be correlated with sarcoma grade and overall survival. This has led to interest in alternative PET tracers to assess the biological characteristics of tumors and guide treatment decisions. Here we investigate novel PET/CT tracers used for the evaluation of sarcomas over the past 20 years and summarize what we have learned about sarcoma tumor biology from these studies.

【 授权许可】

CC BY-NC