Correlation Between Glycolytic Phenotype and Tumor Grade in Soft-Tissue Sarcomas by 18F-FDG PET

Journal of Nuclear Medicine

Sarah M. Dry¹  Michael E. Phelps¹  Johannes Czernin¹  David Elashoff¹  Fritz C. Eilber¹  William D. Tap¹  Matthias R. Benz¹  Martin S. Allen-Auerbach¹ 

关键词: sarcoma;    PET;    ¹⁸F-FDG;    glycolytic phenotype;   

DOI  :  10.2967/jnumed.109.074229

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Tumor glycolytic phenotyping can be accomplished with 18F-FDG PET. Tumor 18F-FDG uptake correlates with tumor grade in several cancers. However, the role of 18F-FDG PET for the grading of soft-tissue sarcomas (STSs) warrants further research. Methods: One hundred two patients (48 men and 54 women; mean age ± SD, 50 ± 17 y) with 12 STS subtypes underwent 18F-FDG PET/CT before treatment. Tumor 18F-FDG uptake, expressed as maximum standardized uptake value (SUVmax), was compared among subtypes and correlated with histopathologic grade. Two frequently used sarcoma grading systemsthe 3-tier system of the French Federation of Cancer Centers Sarcoma Group (Fédération Nationale des Centres de Lutte Contre le Cancer [FNCLCC]) and a 2-tier system (low grade vs. high grade)were used. Results: More than 90% of STSs (93/102) exhibited a strong glycolytic phenotype (SUVmax, 2.7–52.2 g/mL). Tumor SUVmax differed significantly among tumor grades (P < 0.001 for the 3- and 2-tier grading systems). The FNCLCC and 2-tier grading systems predicted tumor grade with similar accuracy (area under the curve, 0.83 and 0.85, respectively; P = 0.35). SUVmax differed significantly among histologic subtypes (P = 0.03) in the entire population but not when high-grade STSs were analyzed separately (P = 0.31). Conclusion: The tumor glycolytic phenotype correlated significantly with histologic grade as determined by both the FNCLCC and 2-tier (high vs. low) grading systems. 18F-FDG PET cannot be used to reliably distinguish among grade 2 and 3 STSs (by FNCLCC) and the various subtypes.

【 授权许可】

Unknown