Minimal residual disease in prostate cancer patients after primary treatment: theoretical considerations, evidence and possible use in clinical management

Biological research: BR

Nigel P. Murray¹ 

[1] Circulating Tumor Cell Unit, Faculty of Medicine, University Finis Terrae, Santiago, Chile

关键词: Prostate cancer;    Circulating tumor cells;    Tumor cell dissemination;    Dormancy;    Micrometastasis;    Phenotype;    Treatment;   

DOI  :  10.1186/s40659-018-0180-9

学科分类：生物科学（综合）

来源: BioMed Central

【 摘 要 】

Minimal residual disease is that not detected by conventional imaging studies and clinically the patient remains disease free. However, with time these dormant cells will awaken and disease progression occurs, resulting in clinically and radiological detectable metastatic disease. This review addresses the concept of tumor cell dissemination from the primary tumor, the micrometastatic niche and tumor cell survival and finally the clinical utility of detecting and characterizing these tumor cells in order to guide management decisions in treating patients with prostate cancer.

【 授权许可】

CC BY