m-RNA mammaglobin expression in metastatic breast cancer patient at Medan city, Indonesia

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Rimbun, S.^1 ; Siregar, Y.^2

Master Program of Biomedical Science, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^1

Department of Biochemistry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^2

关键词: Circulating tumor cells;    Clinical problems;    Histologic grade;    Intra-ductal carcinoma;    Invasive lobular carcinoma;    Metastatic tumors;    Over-expression;    Peripheral blood;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012127/pdf
DOI  :  10.1088/1755-1315/125/1/012127

来源: IOP

【 摘 要 】

Breast cancer is the most common causes of women's death in the world. Metastatic spread presents a major clinical problem in about 30% of the patients. The study aims to investigate the clinical reliability of mammaglobin mRNA as a marker of circulating cancer cells in breast cancer patients. The positivity of blood was analyzed in relation to clinical and pathological characteristics. This study was on 29 breast cancer patients (13 metastatic, 16 non- metastatic patients), where28 were invasive intraductal carcinoma type and 1 was invasive lobular carcinoma type. Breast cancer patients were according to the histologic grade into grade I (7 patients),grade II (6 patients) and grade III (15 patients). All individuals included in this study were subjected to detection of mammaglobin m-RNA of circulating tumor cells in peripheral blood using RT-PCR technique. Positivity for mammaglobin in blood samples was in 38% of patients with metastatic but not in the non-metastatic patients. The presence of mammaglobin correlated with metastatic tumor (P = 0.011). Mammaglobin overexpression in breast tissue was significantly positive in low-grade tumors (I and II).