Control of asymmetric cell division in early C. elegans embryogenesis: teaming-up translational repression and protein degradation

BMB Reports

Sue-Yun Hwang^1,2¹  Lesilee S. Rose^3³ 

[1] Department of Animal Biotechnology, Graduate School of Informatics and Biotechnology^1;Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA^3;Institute of Genetic Engineering, Hankyong National University, Ansung 456-749, Korea^2

关键词: Asymmetric division;   

DOI  :  

学科分类：生物化学/生物物理

来源: Korean Society for Biochemistry and Molecular Biology

【 摘 要 】

Asymmetric cell division is a fundamental mechanism for the generation of body axes and cell diversity during early embryogenesis in many organisms. During intrinsically asymmetric divisions, an axis of polarity is established within the cell and the division plane is oriented to ensure the differential segregation of developmental determinants to the daughter cells. Studies in the nematode Caenorhabditis elegans have contributed greatly to our understanding of the regulatory mechanisms underlying cell polarity and asymmetric division. However, much remains to be elucidated about the molecular machinery controlling the spatiotemporal distribution of key components. In this review we discuss recent findings that reveal intricate interactions between translational control and targeted proteolysis. These two mechanisms of regulation serve to carefully modulate protein levels and reinforce asymmetries, or to eliminate proteins from certain cells.

【 授权许可】

Unknown