Antifungal activity of Cymbopogon winterianus jowitt ex bor against Candida albicans

Revista de microbiologia

Lima, Igara Oliveira¹  Luna, Giliara Carol Diniz Gomes de²  Oliveira, Wylly Araújo de³  Pereira, Fillipe de Oliveira⁴ 

[1] Instituto Federal de Educação, Ciência e Tecnologia da Paraíba, João Pessoa, Brasil;Universidade Federal da Paraíba;Universidade Federal da Paraíba, João Pessoa, Brasil;Universidade Federal de Campina Grande, Cuité, Brasil

关键词: Candida albicans;    antifungal;    Cymbopogon winterianus.;   

DOI  :  10.1590/S1517-83822011000200004

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Microbiologia / Brazilian Society for Microbiology

【 摘 要 】

Candida albicans is an opportunistic yeast and a member of the normal human flora that commonly causes infections in patients with any type of deficiency of the immune system. The essential oils have been tested for antimycotic activity and pose much potential as antifungal agents. This work investigated the activity of the essential oil of Cymbopogon winterianus against C. albicans by MIC, MFC and time-kill methods. The essential oil (EO) was obtained by hydrodistillation using a Clevenger-type apparatus. It was tested fifteen strains of C. albicans. The MIC was determined by the microdilution method and the MFC was determined when an aliquot of the broth microdilution was cultivated in SDA medium. The phytochemical analysis of EO showed presence of citronellal (23,59%), geraniol (18,81%) and citronellol (11,74%). The EO showed antifungal activity, and the concentrations 625 µg/mL and 1250 µg/mL inhibited the growth of all strains tested and it was fungicidal, respectively. The antimicrobial activity of various concentrations of EO was analyzed over time, it was found concentration-dependent antifungal activity, whose behavior was similar to amphotericin B and nystatin.

【 授权许可】

CC BY-NC