Antifungal activity of Cymbopogon winterianus jowitt ex bor against Candida albicans

Brazilian Journal of Microbiology

Wylly Araújo De Oliveira²  Fillipe De Oliveira Pereira²  Giliara Carol Diniz Gomes De Luna¹  Igara Oliveira Lima²  Paulo Alves Wanderley¹  Rita Baltazar De Lima¹  Edeltrudes De Oliveira Lima² 

[1] ,Universidade Federal da Paraíba Centro de Ciências da Saúde Laboratório de Tecnologia FarmacêuticaJoão Pessoa PB ,Brasil

关键词: Candida albicans;    antifungal;    Cymbopogon winterianus;   

DOI  :  10.1590/S1517-83822011000200004

来源: SciELO

【 摘 要 】

Candida albicans is an opportunistic yeast and a member of the normal human flora that commonly causes infections in patients with any type of deficiency of the immune system. The essential oils have been tested for antimycotic activity and pose much potential as antifungal agents. This work investigated the activity of the essential oil of Cymbopogon winterianus against C. albicans by MIC, MFC and time-kill methods. The essential oil (EO) was obtained by hydrodistillation using a Clevenger-type apparatus. It was tested fifteen strains of C. albicans. The MIC was determined by the microdilution method and the MFC was determined when an aliquot of the broth microdilution was cultivated in SDA medium. The phytochemical analysis of EO showed presence of citronellal (23,59%), geraniol (18,81%) and citronellol (11,74%). The EO showed antifungal activity, and the concentrations 625 µg/mL and 1250 µg/mL inhibited the growth of all strains tested and it was fungicidal, respectively. The antimicrobial activity of various concentrations of EO was analyzed over time, it was found concentration-dependent antifungal activity, whose behavior was similar to amphotericin B and nystatin.

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