Neutralization Potency of Sera from Vietnamese Patients with Japanese Encephalitis (JE) against Genotypes I and V JE Viruses

Japanese journal of infectious diseases

Shigeru Tajima¹  Thu Trang Nguyen²  Thi Thu Thuy Nguyen³  Makiko Ikeda⁴ 

[1] Department of Virology I, National Institute of Infectious Diseases;Department of Virology, Institute of Tropical Medicine, Nagasaki University;Department of Virology, National Institute of Hygiene and Epidemiology;Vietnam Research Station, National Institute of Hygiene and Epidemiology-Nagasaki University

关键词: Japanese encephalitis;    Japanese encephalitis virus;    genotype;    neutralization test;   

DOI  :  10.7883/yoken.JJID.2018.232

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

Japanese encephalitis virus (JEV) is classified into 5 genotypes (GI, GII, GIII, GIV, and GV), and the GI and GIII strains are the most widely distributed in JE endemic areas. In recent years, GV JEV has been detected in China and Korea, suggesting that GV JEV may invade other JE endemic areas, including Vietnam, and that more attention should be paid to the JEV strains circulating in these areas. In this study, we investigated the neutralization ability of the sera collected from 22 Vietnamese patients with JE who lived in northern Vietnam against the GI and GV JEV strains. In most cases, the ratios of the titer against GV to that against GI (GV:GI) were equal to or less than 1:4. However, the titer against GV JEV was equivalent (1:1) to that against GI JEV in only a few cases, and no serum had a ratio higher than 1:1. Thus, our results did not show convincing evidence that GV JEV was emerging in northern Vietnam in 2014.

【 授权许可】

Unknown