Comparison of Neutralizing Antibody Titers against Japanese Encephalitis Virus Genotype V Strain with Those against Genotype I and III Strains in the Sera of Japanese Encephalitis Patients in Japan in 2016

Japanese journal of infectious diseases

Takahiro Maeki¹  Kana Miura²  Shigeru Tajima³  Koh Tadokoro⁴  Aung Kyaw Kyaw⁵  Fumiaki Matsumoto⁶  Kodai Negishi⁷  Akira Yoshikawa⁸  Ayaka Yamashita⁹  Yuji Noguchi^1,10 

[1] Department of Virology I, National Institute of Infectious Diseases;Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University;Institute of Tropical Medicine, Nagasaki University;Kanagawa Prefectural Institute of Public Health;Nagasaki Prefectural Institute of Environment and Public Health;Nagasaki Prefecture Tsushima Hospital;Shimane Prefectural Institute of Public Health and Environmental Science;Shizuoka Institute of Environment and Hygiene;Wakayama Medical University;Yamanashi Institute of Public Health and Environment

关键词: Japanese encephalitis virus;    JEV;    neutralization test;    genotype V;   

DOI  :  10.7883/yoken.JJID.2018.126

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

Japanese encephalitis (JE) is an acute viral disease caused by the Japanese encephalitis virus (JEV). JEV strains are classified into 5 genotypes (I–V). JEV genotype V strains have never been detected in Japan to date, but they were recently detected in South Korea. In the present analysis, we tried to determine if a JEV genotype V strain caused any JE case in Japan in 2016. Serum and cerebrospinal fluid samples were collected from 10 JE patients reported in Japan in 2016. JEV RNA was not detected in any of the samples. Although JEV is a single-serotype virus, it can be expected that the neutralizing antibody titers against JEV genotype V strains are higher than those against genotype I and III strains in the serum of patients with JE in Japan whose causative JEV was the genotype V strain. The neutralizing antibody titers against the JEV genotype V strain were not higher than those against the genotype I or III strain in any serum samples. Therefore, the evidence that the JEV genotype V strain caused any JE case in Japan in 2016 was absent.

【 授权许可】

Unknown