Real-world experience of fingolimod in patients with multiple sclerosis (MS Fine): An observational study in the UK

Multiple Sclerosis Journal – Experimental, Translational and Clinical

GordonMazibrada¹ 

关键词: Multiple sclerosis;    fingolimod;    real-world;    observational study;    relapsing–remitting multiple sclerosis;    relapsing multiple sclerosis;   

DOI  :  10.1177/2055217318801638

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

BackgroundFingolimod is approved for the treatment of highly active relapsing–remitting multiple sclerosis in Europe. There is limited information on its effectiveness and safety in clinical practice within the UK.ObjectiveTo evaluate retrospectively the effectiveness and safety of fingolimod in patients with relapsing–remitting multiple sclerosis who were prescribed fingolimod by UK neurologists within the National Health Service.MethodsThis was a multicentre, observational study conducted in the UK. Patients were initiated on fingolimod 0.5 mg 12 months before inclusion in the study. Key efficacy outcomes included annualised relapse rate and the proportion of patients free from relapses, disability progression and clinical and radiological disease activity at 12 months following fingolimod initiation. Resource utilisation and safety outcomes were also assessed.ResultsIn 12 months of treatment with fingolimod, the mean annualised relapse rate was reduced by 79%, the majority of patients were free from re...

【 授权许可】

CC BY-NC