Sociedade Brasileira de Medicina Tropical. Revista | |
Prevalence of low bone mass and changes in vitamin D levels in human immunodeficiency virus-infected adults unexposed to antiretrovirals | |
Guimarães, Nathalia Sernizon1  | |
[1] Universidade Federal de Minas Gerais, Belo Horizonte, Brazil | |
关键词: Bone mass; Vitamin D; HIV; People living with HIV; Biomarker.; | |
DOI : 10.1590/0037-8682-0475-2017 | |
学科分类:农业科学(综合) | |
来源: Sociedade Brasileira de Medicina Tropical | |
【 摘 要 】
INTRODUCTION:The prevalence of low bone mass is 3 times higher in people living with human immunodeficiency virus (PLWH) and using antiretrovirals than in the HIV-unaffected population. Changes in vitamin D levels is one of the factors associated with decreased bone mass. The objective of this study is to evaluate the low bone mass and altered vitamin D levels in PLWH who have not been exposed to antiretrovirals.METHODS:A cross-sectional study was carried out with HIV-infected individuals between the ages of 18 and 55 years immediately prior to the start of antiretroviral therapy in a specialized reference center focusing on infectious and parasitic diseases. Results of clinical examination (patient’s weight, height, blood pressure, and clinical history), laboratory tests, and X-ray absorptiometry, were collected.RESULTS: Sixty patients were included, with a mean age of 34 years. Nine (16.7%) patients presented with low bone mass and 4 (7.1%) patients showed low total femur BMD. Analysis revealed that 23.3% and 36.7% of the patients had deficient and insufficient levels of 25-hydroxyvitamin D3, respectively.CONCLUSIONS:Our study population presented with compromised bone health and with low bone mineral density and 25-(OH)-vitamin D levels.
【 授权许可】
CC BY
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